Erratum to: ‘MicroRNA target prediction using thermodynamic and sequence curves’
نویسندگان
چکیده
منابع مشابه
MicroRNA target prediction using thermodynamic and sequence curves
Background: MicroRNAs (miRNAs) are small regulatory RNA that mediate RNA interference by binding to various mRNA target regions. There have been several computational methods for the identification of target mRNAs for miRNAs. However, these have considered all contributory features as scalar representations, primarily, as thermodynamic or sequence-based features. Further, a majority of these me...
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Many recent studies have shown that access of animal microRNAs (miRNAs) to their complementary sites in target mRNAs is determined by several sequence-specific determinants beyond the seed regions in the 5′ end of miRNAs. These factors have been related to the repressive power of miRNAs and used in some programs to predict the efficacy of miRNA complementary sites. However, these factors have n...
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More recent evidence has shown that access of animal microRNAs (miRNAs) to their complementary sites in target mRNAs is determined by more sequence-specific determinants than the seed regions in the 5' end of miRNAs. Although these factors have been shown to be related to the repressive power of miRNAs and used, in separate programs, to predict the efficacy of miRNA complementary sites, it rema...
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BACKGROUND MicroRNAs are known to be generated from primary transcripts mainly through the sequential cleavages by two enzymes, Drosha and Dicer. The sequence of a mature microRNA, especially the 'seeding sequence', largely determines its binding ability and specificity to target mRNAs. Therefore, methods that predict mature microRNA sequences with high accuracy will benefit the identification ...
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Introduction: The prediction of microRNAs related to target genes using bioinformatics tools saves time and costs of the experimental analyses. In the present study, the prediction of microRNA target genes relevant to Alzheimer’s Diseases (AD) were compared with the experimentally reported data using different bioinformatics tools. Method: A total of 41 microRNAs associated with 21 essential ge...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2016
ISSN: 1471-2164
DOI: 10.1186/s12864-016-2367-1